TY - JOUR AU - Zhao, Yi AU - Zhong, Yi AU - Xiong, Mengqi AU - Huang, Linlin AU - Ye, Xiujin AU - He, Jingsong PY - 2025/5/15 TI - Incidence, Prognostic Factors, and Treatment Impact on Survival in Natural Killer/T-Cell Lymphoma: Population-Based Study in the United States JO - JMIR Form Res SP - e70129 VL - 9 KW - NK/T-cell lymphoma KW - incidence KW - prognostic factors KW - chemoradiotherapy KW - SEER N2 - Background: Natural killer/T-cell lymphoma (NKTL) is a rare malignancy of mature natural killer/T-cells, predominantly found in Asian and South/Central American populations, with limited studies conducted in Europe and the United States. Objective: The aim of this study is to present an overview of the incidence rate, demographic and clinical characteristics, treatment options, overall survival (OS), and factors influencing OS of NKTL in the United States. Methods: We used data from the Surveillance, Epidemiology, and End Results 17 database to analyze NKTL cases recorded between 2000 and 2020. In a cohort of 1162 patients with NKTL, we calculated the incidence rates and performed statistical analyses to evaluate OS, the effect of radiotherapy and chemotherapy on survival, and lymphoma-specific survival. Results: The mean annual incidence rate of NKTL in the United States was 0.067 per 100,000, with higher rates observed in men compared to women, and an increase noted with age. However, there has been no significant rise in incidence over recent years. Significant racial disparities were observed, with higher incidence rates in non-Hispanic Asian or Pacific Islanders and Hispanic people. The median survival time for patients with NKTL was 21 months, with a 5-year OS rate of 39.5%, which has shown improvement in recent years. Key independent prognostic factors impacting patient survival included age at diagnosis, clinical stage, nasal type presentation, presence of systemic symptoms, and treatment modality. Patients receiving combined radiotherapy and chemotherapy exhibited the best outcomes, with a median OS of 138 months and a 5-year OS rate of 58%. This survival benefit remained consistent even in patients with stage I/localized nasal type lymphoma, achieving a 5-year OS rate of 73.3%. Conclusions: The incidence of NKTL has remained stable in recent years. Patients with the nasal type generally experience better survival outcomes. The use of combined radiotherapy and chemotherapy appears to enhance survival, though further validation through prospective multicenter clinical trials is necessary. UR - https://formative.jmir.org/2025/1/e70129 UR - http://dx.doi.org/10.2196/70129 ID - info:doi/10.2196/70129 ER - TY - JOUR AU - Schubert, Cicero Marc AU - Soyka, Stella AU - Wick, Wolfgang AU - Venkataramani, Varun PY - 2025/4/24 TI - Guideline-Incorporated Large Language Model-Driven Evaluation of Medical Records Using MedCheckLLM JO - JMIR Form Res SP - e53335 VL - 9 KW - large language models KW - AI KW - electron medical records KW - checklists KW - LLM KW - language model KW - NLP KW - natural language processing KW - records KW - documentation KW - documents KW - framework KW - conceptual KW - machine learning KW - artificial intelligence KW - evidence KW - evaluate KW - evaluation KW - guideline KW - health care N2 - Abstract: The study introduces MedCheckLLM, a large language model?driven framework that enhances medical record evaluation through a guideline-in-the-loop approach by integrating evidence-based guidelines. UR - https://formative.jmir.org/2025/1/e53335 UR - http://dx.doi.org/10.2196/53335 ID - info:doi/10.2196/53335 ER - TY - JOUR AU - Cook, Nicole AU - Biel, M. Frances AU - Bet, Ann Kerry AU - Sills, R. Marion AU - Al Bataineh, Ali AU - Rivera, Pedro AU - Templeton, R. Anna AU - Cartwright, Natalie PY - 2025/4/21 TI - Engaging Stakeholders With Professional or Lived Experience to Improve Firearm Violence Lexicon Development JO - JMIR Form Res SP - e68105 VL - 9 KW - firearm violence KW - firearm injury KW - stakeholder engagement KW - natural language processing KW - electronic health record UR - https://formative.jmir.org/2025/1/e68105 UR - http://dx.doi.org/10.2196/68105 ID - info:doi/10.2196/68105 ER - TY - JOUR AU - Ghossein, Jamie AU - Hryciw, N. Brett AU - Ramsay, Tim AU - Kyeremanteng, Kwadwo PY - 2025/3/28 TI - The AI Reviewer: Evaluating AI?s Role in Citation Screening for Streamlined Systematic Reviews JO - JMIR Form Res SP - e58366 VL - 9 KW - article screening KW - artificial intelligence KW - systematic review KW - AI KW - large language model KW - LLM KW - screening KW - analysis KW - reviewer KW - app KW - ChatGPT 3.5 KW - chatbot KW - dataset KW - data KW - adoption UR - https://formative.jmir.org/2025/1/e58366 UR - http://dx.doi.org/10.2196/58366 ID - info:doi/10.2196/58366 ER - TY - JOUR AU - Kautsar, Prawira Angga AU - Sinuraya, Kurnia Rano AU - van der Schans, Jurjen AU - Postma, Jacobus Maarten AU - Suwantika, A. Auliya PY - 2025/3/27 TI - Exploring Public Sentiment on the Repurposing of Ivermectin for COVID-19 Treatment: Cross-Sectional Study Using Twitter Data JO - JMIR Form Res SP - e50536 VL - 9 KW - COVID-19 KW - ivermectin KW - sentiment analysis KW - Twitter KW - social media KW - public health KW - misinformation KW - geolocation analysis UR - https://formative.jmir.org/2025/1/e50536 UR - http://dx.doi.org/10.2196/50536 UR - http://www.ncbi.nlm.nih.gov/pubmed/ ID - info:doi/10.2196/50536 ER - TY - JOUR AU - Rajamani, Sripriya AU - Austin, Robin AU - Richwine, Chelsea AU - Britt-Lalich, Malin AU - Thakur, Madhur AU - Odowa, Yasmin AU - Jantraporn, Ratchada AU - Marquard, Jenna PY - 2024/10/11 TI - Understanding Patient Portal Uses and Needs: Cross-Sectional Study in a State Fair Setting JO - JMIR Form Res SP - e64085 VL - 8 KW - patient portals KW - patient engagement KW - health information technology KW - consumer health informatics KW - health informatics KW - use KW - online access KW - medical records KW - data access KW - functionality UR - https://formative.jmir.org/2024/1/e64085 UR - http://dx.doi.org/10.2196/64085 UR - http://www.ncbi.nlm.nih.gov/pubmed/ ID - info:doi/10.2196/64085 ER - TY - JOUR AU - Wisniewski, Payson AU - Depuy, Julia AU - Kim, Cassandra AU - Garrison, Olivia AU - Jerome, J. Gerald PY - 2024/10/7 TI - Supporting Weight Loss Among Parents of Children With a Disability: Lessons Learned From a Single-Arm Pilot Study JO - JMIR Form Res SP - e63858 VL - 8 KW - weight loss KW - obesity KW - disability KW - parent KW - family KW - child KW - weight loss intervention UR - https://formative.jmir.org/2024/1/e63858 UR - http://dx.doi.org/10.2196/63858 UR - http://www.ncbi.nlm.nih.gov/pubmed/39374058 ID - info:doi/10.2196/63858 ER - TY - JOUR AU - Zhang, Boyan AU - Du, Yueqi AU - Duan, Wanru AU - Chen, Zan PY - 2024/8/5 TI - Benchmarking Large Language Models for Cervical Spondylosis JO - JMIR Form Res SP - e55577 VL - 8 KW - cervical spondylosis KW - large language model KW - LLM KW - patient KW - ChatGPT UR - https://formative.jmir.org/2024/1/e55577 UR - http://dx.doi.org/10.2196/55577 UR - http://www.ncbi.nlm.nih.gov/pubmed/ ID - info:doi/10.2196/55577 ER - TY - JOUR AU - Bravata, Dena AU - Russell, Daniel AU - Fellows, Annette AU - Goldman, Ron AU - Pace, Elizabeth PY - 2024/7/24 TI - Digitally Enabled Peer Support and Social Health Platform for Vulnerable Adults With Loneliness and Symptomatic Mental Illness: Cohort Analysis JO - JMIR Form Res SP - e58263 VL - 8 KW - peer support KW - social isolation KW - loneliness KW - depression KW - depressive KW - mental health KW - anxiety KW - quality of life KW - isolation KW - isolated KW - online support KW - digital health KW - vulnerable KW - race KW - racial ethnic KW - ethnicity KW - gender KW - socioeconomic KW - demographic UR - https://formative.jmir.org/2024/1/e58263 UR - http://dx.doi.org/10.2196/58263 UR - http://www.ncbi.nlm.nih.gov/pubmed/38941568 ID - info:doi/10.2196/58263 ER - TY - JOUR AU - Dagli, Marcel Mert AU - Oettl, Conrad Felix AU - Gujral, Jaskeerat AU - Malhotra, Kashish AU - Ghenbot, Yohannes AU - Yoon, W. Jang AU - Ozturk, K. Ali AU - Welch, C. William PY - 2024/6/7 TI - Clinical Accuracy, Relevance, Clarity, and Emotional Sensitivity of Large Language Models to Surgical Patient Questions: Cross-Sectional Study JO - JMIR Form Res SP - e56165 VL - 8 KW - artificial intelligence KW - AI KW - natural language processing KW - NLP KW - large language model KW - LLM KW - generative AI KW - cross-sectional study KW - health information KW - patient education KW - clinical accuracy KW - emotional sensitivity KW - surgical patient KW - surgery KW - surgical UR - https://formative.jmir.org/2024/1/e56165 UR - http://dx.doi.org/10.2196/56165 UR - http://www.ncbi.nlm.nih.gov/pubmed/38848553 ID - info:doi/10.2196/56165 ER - TY - JOUR AU - Baus, Adam AU - Boatman, D. Dannell AU - Calkins, Andrea AU - Pollard, Cecil AU - Conn, Ellen Mary AU - Subramanian, Sujha AU - Kennedy-Rea, Stephenie PY - 2024/4/19 TI - A Health Information Technology Protocol to Enhance Colorectal Cancer Screening JO - JMIR Form Res SP - e55202 VL - 8 KW - electronic health record KW - EHR KW - colorectal cancer screening KW - health information technology KW - cancer KW - colorectal cancer UR - https://formative.jmir.org/2024/1/e55202 UR - http://dx.doi.org/10.2196/55202 UR - http://www.ncbi.nlm.nih.gov/pubmed/38640474 ID - info:doi/10.2196/55202 ER - TY - JOUR AU - van Alen, Marie Catharina AU - Brenner, Alexander AU - Warnecke, Tobias AU - Varghese, Julian PY - 2024/3/20 TI - Smartwatch Versus Routine Tremor Documentation: Descriptive Comparison JO - JMIR Form Res SP - e51249 VL - 8 KW - Parkinson disease KW - tremor KW - smart wearables KW - smartwatch KW - mobile apps KW - movement disorders KW - tremor documentation KW - tremor occurrence KW - tremor score UR - https://formative.jmir.org/2024/1/e51249 UR - http://dx.doi.org/10.2196/51249 UR - http://www.ncbi.nlm.nih.gov/pubmed/38506919 ID - info:doi/10.2196/51249 ER - TY - JOUR AU - Jones, Grant AU - Herrmann, Felipe AU - Bear, Adam AU - Carhart-Harris, Robin AU - Kettner, Hannes PY - 2024/3/4 TI - The Relationship Between Changes in Mindfulness and Subsequent Changes in Well-Being Following Psychedelic Use: Prospective Cohort Study JO - JMIR Form Res SP - e54632 VL - 8 KW - psychedelics KW - mindfulness KW - observational KW - web-based survey KW - psychedelic KW - meditation KW - mental health KW - anxiety KW - depression KW - survey KW - surveys KW - drug KW - drugs KW - substance use KW - hallucinogen KW - hallucinogens UR - https://formative.jmir.org/2024/1/e54632 UR - http://dx.doi.org/10.2196/54632 UR - http://www.ncbi.nlm.nih.gov/pubmed/38437005 ID - info:doi/10.2196/54632 ER -